Campbell R J, Bourne W M
Ophthalmology. 1981 Dec;88(12):1231-8. doi: 10.1016/s0161-6420(81)34867-2.
A unilateral, apparently nonfamilial disease process affecting the interpalpebral portion of the corneal epithelium is reported. The patient, a 62-year-old man, was in good general health; he had no disease of the skin or mucous membranes and no history of trauma. Severe intermittent discomfort of the left eye had been present for several months. Corneal epithelial scrapings were performed on two occasions with a one-year interval, the condition having recurred during the intervening months. Material from both biopsy specimens showed dysplasia of the epithelium with foci of acantholysis and dyskeratosis and features of apoptosis. Transmission electron microscopic findings included intracytoplasmic desmosomes, conspicuous thickened tonofibrils, irregular convoluted cytoplasmic membranes, and dyskeratotic bodies.
报告了一例影响角膜上皮睑裂部的单侧、显然非家族性的疾病过程。患者为一名62岁男性，全身健康状况良好；无皮肤或黏膜疾病，也无外伤史。左眼严重间歇性不适已持续数月。间隔一年进行了两次角膜上皮刮片检查，在此期间病情复发。两份活检标本的材料均显示上皮发育异常，伴有棘层松解灶和角化不良，以及凋亡特征。透射电子显微镜检查结果包括胞质内桥粒、明显增粗的张力原纤维、不规则卷曲的细胞质膜和角化不良小体。
