Stapleton F B, Arant B S
Pediatr Res. 1981 Dec;15(12):1513-6. doi: 10.1203/00006450-198112000-00012.
Renal uric acid excretion was examined in 35 mongrel puppies at 1, 30, 60 and 90 days of age and in seven mature mongrel dogs. Uric acid concentrations in plasma and urine were determined using a uricase fluorometric method. Clearance of inulin increased with postnatal age; however, fractional excretion of uric acid (FEUA) decreased from 83% at birth to 51% at 90 days of age (r = -0.675, P less than 0.001). Filtered uric acid and net reabsorption of uric acid increased with postnatal development. The decline in FEUA with postnatal age was unrelated to binding of uric acid to plasma proteins or to urine flow rate. A direct correlation was observed between clearance of uric acid (CUA) and clearance of sodium (CNa) during early development (r = 0.48, P less than 0.001). These data indicate that postnatal maturational patterns of renal urate excretion in mongrel puppies are similar to human newborns.
对35只杂种幼犬在1日龄、30日龄、60日龄和90日龄时以及7只成年杂种犬的肾脏尿酸排泄情况进行了检查。采用尿酸酶荧光法测定血浆和尿液中的尿酸浓度。菊粉清除率随出生后年龄增长而增加；然而，尿酸分数排泄率（FEUA）从出生时的83%降至90日龄时的51%（r = -0.675，P < 0.001）。滤过尿酸和尿酸净重吸收随出生后发育而增加。FEUA随出生后年龄的下降与尿酸与血浆蛋白的结合或尿流率无关。在早期发育过程中，观察到尿酸清除率（CUA）与钠清除率（CNa）之间存在直接相关性（r = 0.48，P < 0.001）。这些数据表明，杂种幼犬肾脏尿酸盐排泄的出生后成熟模式与人类新生儿相似。
