Stephens D N, Nash S C, Proffitt C
Pflugers Arch. 1981 Nov;392(1):7-12. doi: 10.1007/BF00584574.
In order to investigate the role of brown adipose tissue (BAT) in diet-induced thermogenesis (DIT), a selection of palatable, energy-dense foods (Cafeteria diet) was used to increase the energy intakes of adult and weanling male rats, from some of which interscapular BAT (IBAT) had been surgically excised. Removal of IBAT had no effect upon energy intakes of the cafeteria-fed rats, nor of controls fed a pelleted stock diet. The rate of weight gain of intact controls was similar for the two diets, but adults with IBAT removed and fed with the cafeteria diet gained weight more rapidly than those fed the stock diet. Similarly, although intact weanlings did not exhibit excess weight gain when fed the cafeteria diet, removal of IBAT did result in more rapid weight gain of the cafeteria-fed weanlings relative to their stock-fed siblings. Nevertheless, total carcass energy was increased by some 20% in cafeteria-fed animals, irrespective of whether they had had IBAT removed. Thus there was no evidence of removal of IBAT having improved the efficiency of energy utilisation for growth. The failure to find evidence for altered levels of energy expenditure following removal of IBAT does not necessarily contradict the hypothesis that BAT mediates DIT, however, since, following removal of IBAT, there was hypertrophy of remaining BAT sites which may have compensated for the BAT removed.
为了研究棕色脂肪组织（BAT）在饮食诱导产热（DIT）中的作用，选用了一些美味、能量密集的食物（自助餐饮食）来增加成年和断奶雄性大鼠的能量摄入，其中部分大鼠的肩胛间棕色脂肪组织（IBAT）已通过手术切除。切除IBAT对自助餐喂养大鼠以及喂食颗粒饲料的对照大鼠的能量摄入均无影响。两种饮食条件下，完整对照大鼠的体重增加速率相似，但切除IBAT并喂食自助餐饮食的成年大鼠比喂食颗粒饲料的大鼠体重增加更快。同样，尽管完整的断奶大鼠在喂食自助餐饮食时并未出现体重过度增加的情况，但相对于喂食颗粒饲料的同窝断奶大鼠，切除IBAT确实导致喂食自助餐饮食的断奶大鼠体重增加更快。然而，无论是否切除IBAT，自助餐喂养动物的胴体总能量均增加了约20%。因此，没有证据表明切除IBAT提高了能量用于生长的利用效率。然而，切除IBAT后未能找到能量消耗水平改变的证据并不一定与BAT介导DIT的假说相矛盾，因为切除IBAT后，剩余BAT部位出现肥大，这可能补偿了被切除的BAT。
