Vinegar R, Truax J F, Selph J L, Johnston P R, Venable A L, Voelker F A
Proc Soc Exp Biol Med. 1981 Oct;168(1):24-32. doi: 10.3181/00379727-168-41229.
Colchicine produced three effects which modified the acute inflammatory response to carrageenan in the rat pleural cavity: (i) inhibition of neutrophil mobilization and concomitant exudate formation (3 hr); (ii) inhibition of monocyte mobilization (21 hr); and (iii) augmented exudate formation (3 and 21 hr). The 1st effect was related to the intraperitoneal dose of colchicine and occurred only at leukopenic dose levels This effect could not be produced by intrapleural injection of nonleukopenic doses of colchicine. The second effect, on the other hand, was produced by intraperitoneal leukopenic doses and to a lesser extent by intrapleural administration of nonleukopenic doses of colchicine. Importantly, the normal biphasic exudative response to carrageenan developed fully in the absence of monocytes. The third effect, a dose-dependent augmentation of both exudative phases of carrageenan pleurisy, was produced by low, nonleukopenic, intrapleural doses of colchicine. The augmented exudate was sensitive to prostaglandin synthetase inhibitors but not to anti-inflammatory steroids. Neither neutrophils nor monocytes were responsible for the augmented exudate. Colchicine, injected into the rat hindlimb or pleural and peritoneal cavities did not elicit the mobilization of neutrophils or a pleural effusion. In addition, colchicine did not affect the magnitude, temporal development, or decay of the potent edematogenic action of serotonin in the rat hindlimb. Thus irritancy was not responsible for any of the effects of colchicine.
秋水仙碱产生了三种效应，这些效应改变了大鼠胸腔对角叉菜胶的急性炎症反应：（i）抑制中性粒细胞动员及随之而来的渗出物形成（3小时）；（ii）抑制单核细胞动员（21小时）；以及（iii）增强渗出物形成（3小时和21小时）。第一种效应与秋水仙碱的腹腔注射剂量有关，且仅在白细胞减少剂量水平时出现。这种效应不能通过胸膜腔内注射非白细胞减少剂量的秋水仙碱产生。另一方面，第二种效应是由腹腔注射白细胞减少剂量产生的，而胸膜腔内注射非白细胞减少剂量的秋水仙碱产生的程度较小。重要的是，在没有单核细胞的情况下，对角叉菜胶正常的双相渗出反应仍能充分发展。第三种效应，即角叉菜胶性胸膜炎两个渗出期的剂量依赖性增强，是由低剂量、非白细胞减少的胸膜腔内注射秋水仙碱产生的。增强的渗出物对前列腺素合成酶抑制剂敏感，但对抗炎类固醇不敏感。增强的渗出物既不是由中性粒细胞也不是由单核细胞引起的。注入大鼠后肢、胸膜腔和腹腔的秋水仙碱不会引起中性粒细胞动员或胸腔积液。此外，秋水仙碱不影响血清素在大鼠后肢的强效致水肿作用的程度、时间发展或消退。因此，刺激性不是秋水仙碱任何效应的原因。
