晶体诱导的大鼠皮下气囊炎症。
Crystal-induced inflammation in the rat subcutaneous air-pouch.
作者信息
Brooks P M, Burton D, Forrest M J
出版信息
Br J Pharmacol. 1987 Feb;90(2):413-9. doi: 10.1111/j.1476-5381.1987.tb08971.x.
Abstract
Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals initiated acute inflammatory reactions characterized by increased plasma extravasation and polymorphonuclear leukocyte (PMNL) accumulation in the rat subcutaneous air-pouch. Pretreatment of rats with colchicine (1 mg kg-1, s.c.) inhibited PMNL accumulation induced by either crystal type but had a greater inhibitory effect on MSU-induced plasma extravasation compared with that induced by CPPD crystals. Colchicine (1 mg kg-1, s.c.) did not reduce histamine-induced plasma extravasation in the air-pouch. The lipoxygenase product of arachidonic acid metabolism, leukotriene B4 (LTB4), was detected in MSU-induced exudates but not in CPPD-induced exudates. Pretreatment of rats with colchicine (1 mg kg-1, s.c.) inhibited LTB4 production in MSU-induced exudates.
摘要
尿酸单钠（MSU）和二水焦磷酸钙（CPPD）晶体引发急性炎症反应，其特征为大鼠皮下气囊中血浆外渗增加和多形核白细胞（PMNL）积聚。用秋水仙碱（1 mg/kg，皮下注射）预处理大鼠可抑制两种晶体类型诱导的PMNL积聚，但与CPPD晶体诱导的血浆外渗相比，对MSU诱导的血浆外渗具有更大的抑制作用。秋水仙碱（1 mg/kg，皮下注射）并未降低气囊中组胺诱导的血浆外渗。在MSU诱导的渗出物中检测到花生四烯酸代谢的脂氧合酶产物白三烯B4（LTB4），但在CPPD诱导的渗出物中未检测到。用秋水仙碱（1 mg/kg，皮下注射）预处理大鼠可抑制MSU诱导的渗出物中LTB4的产生。
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