Raychaudhuri A, Colombo C, Pastor G, Wong M, Jeng A Y
Research Department, Ciba-Geigy Corporation, Summit, NJ 07901.
Agents Actions. 1991 Sep;34(1-2):251-3. doi: 10.1007/BF01993295.
Injection of 2.5 mg of lambda-carrageenan into the rat pleural cavity resulted in a time-dependent increase in pleural exudate substance P (SP) levels up to 24 hr. Synergistic increases in the exudate formation were observed when a sub-optimal quantity of carrageenan was injected with SP. Pre-treatment of rats with capsaicin at 50 and 100 mg/kg s.c. daily for one week prior to the induction of pleurisy blocked the increase in exudate volume and SP levels when compared to that normally detected after carrageenan injection. These results suggest that inhibition of SP production may improve inflammatory conditions.
向大鼠胸腔内注射2.5毫克λ-角叉菜胶，会导致胸腔渗出液中P物质（SP）水平在长达24小时内随时间增加。当注射次优剂量的角叉菜胶与SP时，可观察到渗出液形成的协同增加。在诱发胸膜炎前一周，每天以50和100毫克/千克的剂量对大鼠进行皮下辣椒素预处理，与角叉菜胶注射后正常检测到的情况相比，可阻断渗出液体积和SP水平的增加。这些结果表明，抑制SP的产生可能改善炎症状况。
