Codish S D, Monaco A P
J Surg Oncol. 1978;10(5):447-55. doi: 10.1002/jso.2930100510.
Bacillus Calmette-Guérin (BCG) was administered in various doses by four different routes to C3H/HeJ mice bearing well-established syngeneic MC-42 fibrosarcomas. Injections of BCG into established primary tumors decreased survival of tumor-bearing mice as compared to saline-injected controls. Of the three dosage groups, high-dose (10(8) viable organisms) intralesional BCG was most detrimental. The injection of low-dose BCG (10(4) organisms) into established tumors or subcutaneously at a distant site also shortened host survival times. Other subcutaneous injections and injections of BCG into the peritoneal or pleural cavities had no significant effect on survival, regardless of dosage. The dose-dependent effects of BCG immunotherapy which may prolong or shorten survival are discussed.
将不同剂量的卡介苗（BCG）通过四种不同途径接种到患有已形成的同基因MC - 42纤维肉瘤的C3H/HeJ小鼠体内。与注射生理盐水的对照组相比，向已形成的原发性肿瘤内注射卡介苗会降低荷瘤小鼠的存活率。在三个剂量组中，高剂量（10⁸ 个活菌体）瘤内注射卡介苗最为有害。向已形成的肿瘤内注射低剂量卡介苗（10⁴ 个菌体）或在远处皮下注射也会缩短宿主存活时间。其他皮下注射以及向腹腔或胸腔内注射卡介苗，无论剂量如何，对存活率均无显著影响。本文讨论了卡介苗免疫疗法可能延长或缩短存活时间的剂量依赖性效应。
