Yarkoni E, Rapp H J
J Natl Cancer Inst. 1979 Aug;63(2):503-5.
Intralesional administration of emulsified croton oil into established syngeneic transplants of murine firosarcoma no. 1023 caused complete regression of the injected tumors in C3H mice without recurrence during the period of observation. In Sewall Wright strain 2 guinea pigs, in contrast to BCG cell wall vaccine which eradicated regional lymph node metastasis as well as dermal transplants, croton oil treatment only delayed the development of metastatic disease despite the fact that the injected skin tumors did not recur. 12-O-Tetradecanoylphorbol 13-acetate (TPA), the active principle of croton oil, incorporated in mineral oil droplets in aqueous suspension, caused regression of murine tumors when injected intralesionally. Aqueous suspensions of TPA failed to eliminate the tumors. Our results suggest that tumor regression induced by croton oil of TPA emulsions was due to indiscriminate destruction of the injected tissue.
将乳化巴豆油瘤内注射到已建立的小鼠1023纤维肉瘤同基因移植瘤中，可使C3H小鼠体内注射部位的肿瘤完全消退，在观察期内无复发。相比之下，在休厄尔·赖特2系豚鼠中，卡介苗细胞壁疫苗可消除区域淋巴结转移以及皮肤移植瘤，而巴豆油治疗仅能延迟转移性疾病的发展，尽管注射的皮肤肿瘤未复发。巴豆油的活性成分十四酰佛波醇-13-乙酸酯（TPA）加入水悬浮液中的矿物油滴中，瘤内注射时可使小鼠肿瘤消退。TPA水悬浮液未能消除肿瘤。我们的结果表明，TPA乳剂中巴豆油诱导的肿瘤消退是由于对注射组织的无差别破坏。
