Carluccio L, Colizza S, Costantino A, Di Paola M, Sopranzi N
J Surg Oncol. 1978;10(6):511-7. doi: 10.1002/jso.2930100606.
Serial CEA levels have been studied preoperatively, and one day, 10--15 days, four months, and eight months after surgery in a group of colon cancer patients who started soon after surgery a protocol of adjuvant immuno(chemo)therapy with Levamisole R and BCG R. Results showed a decrease of mean values of plasma CEA levels from preoperatively to four months after surgery, while eight months after surgery a slight increase was noted. Some of the patients in whom disease recurred showed persistent high levels of CEA, while one patient was consistently a false-negative notwithstanding a bone recurrence. While the prognostic value of serial CEA determinations is confirmed, the possibility of restarting (or intensifying) a protocol of adjuvant immunochemotherapy given high CEA levels and a negative clinical picture is discussed.
对一组结肠癌患者术前以及术后1天、10 - 15天、4个月和8个月的癌胚抗原（CEA）水平进行了连续研究，这些患者术后不久即开始采用左旋咪唑R和卡介苗R进行辅助免疫（化学）治疗方案。结果显示，血浆CEA水平的平均值从术前到术后4个月有所下降，而术后8个月则出现轻微上升。一些疾病复发的患者CEA水平持续较高，而有一名患者尽管出现骨转移复发，但CEA一直呈假阴性。虽然连续CEA测定的预后价值得到了证实，但也讨论了在CEA水平高而临床症状为阴性的情况下重启（或强化）辅助免疫化学治疗方案的可能性。
