Wanebo H J
Surgery. 1981 Mar;89(3):290-5.
Although the carcinoembryonic antigen (CEA) is not specific for colorectal cancer, its strong correlation with many aspects of the disease has made it very useful in clinical management of this malignancy. There is controversy, however, about the real value of CEA determinations in the clinical decision-making process and about their impact on patient prognosis. This review analyzes the relative values of the preoperative CEA and postoperative serial CEA levels, the correlation with different patterns of recurrence, and the potential for detecting early recurrence and selecting patients for second-look surgery. Although there is potential for CEA-directed second-look surgery to retrieve patients through resection of early recurrence and possibly to increase the survival rate, the long-term effects on prognosis are yet to be determined.
虽然癌胚抗原（CEA）并非结直肠癌所特有，但其与该疾病诸多方面的密切关联使其在这种恶性肿瘤的临床管理中非常有用。然而，关于CEA测定在临床决策过程中的实际价值以及它们对患者预后的影响存在争议。本综述分析了术前CEA和术后系列CEA水平的相对价值、与不同复发模式的相关性，以及检测早期复发和选择患者进行二次探查手术的可能性。虽然CEA导向的二次探查手术有可能通过切除早期复发灶来挽救患者并可能提高生存率，但对预后的长期影响尚待确定。
