Wickström I, Stefansson T, Sundström E
Acta Anaesthesiol Scand. 1981 Jun;25(3):258-62. doi: 10.1111/j.1399-6576.1981.tb01647.x.
To study the effect of renal function on the increased serum inorganic fluoride level produced by the metabolism of enflurane, three groups of beagle dogs were exposed to prolonged enflurane anesthesia, 1.25 MAC for 8 h. One group was studied both with and without renal function, one group only without renal function, and one group on two different occasions with renal function intact. Serum inorganic fluoride levels were determined every hour during the enflurane anesthesia and on termination for a further 4 h. In dogs with no renal function, the increase rate and the peak of serum inorganic fluoride level were significantly higher than in dogs with renal function. The average peak level in dogs with renal function was 21.4 mumol/l and in dogs with no renal function 38.4 mumol/l. Renal function was found to have the same capacity to increase the inorganic fluoride elimination from serum as other routes of elimination. At corresponding serum levels, the rate of decrease after terminating enflurane anesthesia was 3.5-4.0 mumol/l/h lower without renal function. Reanesthesia after 3 weeks did not significantly change the serum inorganic fluoride levels compared to the first anesthesia.
为研究肾功能对恩氟烷代谢产生的血清无机氟水平升高的影响，将三组比格犬暴露于长时间的恩氟烷麻醉下，浓度为1.25MAC，持续8小时。一组在有肾功能和无肾功能的情况下均进行研究，一组仅在无肾功能的情况下进行研究，一组在肾功能正常的两种不同情况下进行研究。在恩氟烷麻醉期间每小时测定血清无机氟水平，并在结束后再测定4小时。在无肾功能的犬中，血清无机氟水平的升高速率和峰值显著高于有肾功能的犬。有肾功能的犬的平均峰值水平为21.4μmol/L，无肾功能的犬为38.4μmol/L。发现肾功能与其他消除途径具有相同的增加血清无机氟消除的能力。在相应的血清水平下，无肾功能时恩氟烷麻醉结束后的下降速率比有肾功能时低3.5 - 4.0μmol/L/小时。与第一次麻醉相比，3周后再次麻醉并未显著改变血清无机氟水平。
