Setty O H, Misra U K
Acta Vitaminol Enzymol. 1981;3(2):71-4.
The effect of 33 mg of vitamin A for two days on heart phospholipids and on the molecular species of phosphatidyl-choline and phosphatidyl-ethanolamine of rats has been studied. Vitamin A reduced the amounts of heart total phospholipids, phosphatidyl-choline and its tetraenoic species and of the hexaenoic species of phosphatidyl-ethanolamine. In rats administered vitamin A the incorporation of NaH232PO4 and choline 1,2-14C chloride into total phospholipids and into the phosphatidyl-choline fraction was reduced. The results of the incorporation of NaH232PO4 into the various molecular species of phosphatidyl-choline and phosphatidyl-ethanolamine showed that excess A impaired the synthesis of these phospholipids via the CDP-choline-ethanolamine pathway.
研究了33毫克维生素A连续两天对大鼠心脏磷脂以及磷脂酰胆碱和磷脂酰乙醇胺分子种类的影响。维生素A减少了心脏总磷脂、磷脂酰胆碱及其四烯酸种类以及磷脂酰乙醇胺六烯酸种类的含量。在给予维生素A的大鼠中，NaH₂³²PO₄和氯化胆碱-1,2-¹⁴C掺入总磷脂和磷脂酰胆碱部分的量减少。NaH₂³²PO₄掺入磷脂酰胆碱和磷脂酰乙醇胺各种分子种类的结果表明，过量的维生素A通过CDP-胆碱-乙醇胺途径损害了这些磷脂的合成。
