系谱分析的最佳抽样：患病先证者的亲属
Optimal sampling for pedigree analysis: relatives of affected probands.
作者信息
Thompson E A
出版信息
Am J Hum Genet. 1981 Nov;33(6):968-77.
Abstract
Criteria and rules are derived for the most statistically efficient sampling of relatives of affected probands under a simple class of standard genetic models. Results show that the optimal relative type depends on the alternative hypotheses of particular interest. Thus, there is no uniformly optimal strategy, but the criteria can be used to derive the best strategy in any particular case; examples are given.
摘要
在一类简单的标准遗传模型下，得出了对患病先证者亲属进行统计学上最有效抽样的标准和规则。结果表明，最佳亲属类型取决于特定感兴趣的备择假设。因此，不存在统一的最优策略，但这些标准可用于推导任何特定情况下的最佳策略；文中给出了示例。
相似文献
1
Optimal sampling for pedigree analysis: relatives of affected probands.系谱分析的最佳抽样：患病先证者的亲属
Am J Hum Genet. 1981 Nov;33(6):968-77.
2
Optimal sampling for pedigree analysis: sequential schemes for sibships.家系分析的最优抽样：同胞组的序贯方案
Biometrics. 1981 Jun;37(2):313-25.
3
Inherent intractability of the ascertainment problem for pedigree data: a general likelihood framework.系谱数据确定问题的内在难处理性：一个通用似然框架。
Am J Hum Genet. 1995 Jan;56(1):33-43.
4
Sampling considerations in the gathering and analysis of pedigree data.系谱数据收集与分析中的抽样考量
Am J Hum Genet. 1979 Jan;31(1):62-9.
5
Sampling considerations in the design and analysis of family studies.
Prog Clin Biol Res. 1984;147:349-71.
6
The effects of conditioning on probands to correct for multiple ascertainment.通过条件设定对先证者进行校正以应对多重确证的影响。
Am J Hum Genet. 1984 Nov;36(6):1298-308.
7
Ascertainment in the sequential sampling of pedigrees.系谱序贯抽样中的确诊
Clin Genet. 1977 Oct;12(4):208-12. doi: 10.1111/j.1399-0004.1977.tb00928.x.
8
A general unified framework to assess the sampling variance of heritability estimates using pedigree or marker-based relationships.一个使用系谱或基于标记的关系来评估遗传力估计值抽样方差的通用统一框架。
Genetics. 2015 Jan;199(1):223-32. doi: 10.1534/genetics.114.171017. Epub 2014 Oct 31.
9
Segregation analysis.分离分析
Adv Hum Genet. 1981;11:63-120, 372-3. doi: 10.1007/978-1-4615-8303-5_2.
10
Comparison of ascertainment-bias correction schemes for pedigrees ascertained through multiple probands.通过多个先证者确定的家系的确诊偏倚校正方案比较。
Stat Med. 1985 Apr-Jun;4(2):163-73. doi: 10.1002/sim.4780040207.
引用本文的文献
1
An algorithm for optimal testing in co-segregation analysis.一种共分离分析中的最优检验算法。
Hum Mutat. 2022 May;43(5):547-556. doi: 10.1002/humu.24363. Epub 2022 Apr 7.
2
Comparisons of different sampling designs for the determination of genetic transmission mechanisms in quantitative traits.用于确定数量性状遗传传递机制的不同抽样设计的比较。
Am J Hum Genet. 1984 Sep;36(5):1060-74.
3
Comparison of sequential and fixed-structure sampling of pedigrees in complex segregation analysis of a quantitative trait.复杂数量性状分离分析中系谱的序贯抽样与固定结构抽样的比较
Am J Hum Genet. 1988 Sep;43(3):336-43.
本文引用的文献
1
Schizophrenia: the systematic construction of genetic models.精神分裂症：遗传模型的系统构建
Am J Hum Genet. 1980 Jan;32(1):47-54.
2
Frequency in relatives for an all-or-none trait.全或无性状在亲属中的发生率。
Ann Hum Genet. 1971 Jul;35(1):47-9. doi: 10.1111/j.1469-1809.1956.tb01377.x.
3
Analysis of family resemblance. I. Introduction.家族相似性分析。一、引言。
Am J Hum Genet. 1974 May;26(3):318-30.
4
The inheritance of fingerprint patterns.指纹图案的遗传。
Am J Hum Genet. 1976 May;28(3):280-9.
5
The estimation of pairwise relationships.成对关系的估计。
Ann Hum Genet. 1975 Oct;39(2):173-88. doi: 10.1111/j.1469-1809.1975.tb00120.x.
6
Limits of the general two-allele single locus model with incomplete penetrance.具有不完全外显率的一般双等位基因单基因座模型的局限性。
Ann Hum Genet. 1976 Nov;40(2):231-43. doi: 10.1111/j.1469-1809.1976.tb00186.x.
7
Efficiency and robustness of pedigree segregation analysis.系谱分离分析的效率与稳健性
Am J Hum Genet. 1978 Jan;30(1):28-37.
8
Sampling considerations in the gathering and analysis of pedigree data.系谱数据收集与分析中的抽样考量
Am J Hum Genet. 1979 Jan;31(1):62-9.
9
Linkage analysis and the inheritance of arches in a Habbanite isolate.哈巴尼特孤立群体中足弓的连锁分析与遗传
Am J Hum Genet. 1979 Sep;31(5):620-9.
Zotero 插件