Melcher A, Donald D E
Am J Physiol. 1981 Dec;241(6):H838-49. doi: 10.1152/ajpheart.1981.241.6.H838.
In conscious dogs bilateral carotid occlusion increased arterial pressure by similar amounts at rest (+ 27 mmHg) and during graded exercise (+ 29 mmHg). During exercise stimulus-response curves for arterial pressure and heart rate derived from isolated carotid sinuses were displaced upward proportionately to the work load, but the curve characteristics were unchanged. After acute bilateral vagotomy similar responses to carotid occlusion were obtained at rest (+ 85 mmHg) and at 21% grade (+ 84 mmHg); the range and maximal slope of the arterial pressure stimulus-response curve during exercise was similar to that at rest, but the exercise curve was displaced downward and to the left. It was concluded that the carotid baroreflex was able to modulate arterial pressure as well during running as at rest. Dogs with neither carotid, aortic, or cardiopulmonary receptors able to respond to the exercise stress became and remained hypotensive during mild exercise; during severe exercise hypotension was present initially, but after 90 s arterial pressure recovered toward the preexercise level. The data indicated that arterial and cardiopulmonary baroreceptors have a major role in the support of arterial pressure in the first moments of exercise.
在清醒犬中，双侧颈动脉闭塞在静息时（+27 mmHg）和分级运动时（+29 mmHg）使动脉压升高的幅度相似。运动期间，源自孤立颈动脉窦的动脉压和心率的刺激-反应曲线与工作负荷成比例地向上移位，但曲线特征未变。急性双侧迷走神经切断术后，静息时（+85 mmHg）和21%坡度运动时（+84 mmHg）对颈动脉闭塞获得了相似的反应；运动期间动脉压刺激-反应曲线的范围和最大斜率与静息时相似，但运动曲线向下和向左移位。得出的结论是，颈动脉压力反射在跑步和静息时都能够调节动脉压。既没有颈动脉、主动脉或心肺感受器能够对运动应激作出反应的犬在轻度运动期间会出现并持续低血压；在剧烈运动期间，最初会出现低血压，但90秒后动脉压恢复到运动前水平。数据表明，动脉和心肺压力感受器在运动开始的最初时刻对动脉压的维持起主要作用。
