Brown M P, Stover S M, Kelly R H, Farver T B
J Vet Pharmacol Ther. 1982 Jun;5(2):119-22. doi: 10.1111/j.1365-2885.1982.tb00506.x.
Ten healthy adult mares were given a single intramuscular dose (2.2 mg/kg) of gentamicin sulfate. Over a 48-h period, gentamicin concentrations were measured serially in the serum of all ten mares and in synovial fluid, peritoneal fluid, and urine of six of the mares. The mean peak serum gentamicin concentration was 5.73 micrograms/ml at 1 h. Gentamicin was detected in synovial fluid and peritoneal fluid, with mean peak gentamicin concentrations of 2.41 micrograms/ml and 3.92 micrograms/ml, respectively, observed at 2 h. These concentrations declined in parallel with serum concentrations and were not measurable at 48 h. Urine gentamicin concentration was relatively high, with a mean peak concentration of 424.9 micrograms/ml at 1 h after drug administration.
十匹健康成年母马接受了单次肌肉注射剂量（2.2毫克/千克）的硫酸庆大霉素。在48小时内，连续测量了所有十匹母马血清以及其中六匹母马的滑液、腹腔液和尿液中的庆大霉素浓度。血清中庆大霉素的平均峰值浓度在1小时时为5.73微克/毫升。在滑液和腹腔液中检测到了庆大霉素，在2小时时观察到的庆大霉素平均峰值浓度分别为2.41微克/毫升和3.92微克/毫升。这些浓度与血清浓度平行下降，在48小时时无法检测到。尿液中庆大霉素浓度相对较高，给药后1小时的平均峰值浓度为424.9微克/毫升。
