Disposition kinetics, urinary excretion and dosage regimen of kanamycin in buffalo calves following single intravenous administration.

The disposition kinetics and appropriate dosage regimen for kanamycin were investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight. The distribution and elimination half-lives were 0.12 +/- 0.01 h and 1.94 +/- 0.11 h, respectively. The apparent volume of distribution and total body clearance were 0.2 +/- 0.01 L/kg and 92.9 +/- 3.69 ml/kg/h, respectively. About 74% of the administered dose was excreted in urine in 24 h. A suitable dosage regimen for the intravenous administration of kanamycin was also calculated.