血清蛋白结合及给药方式对五种头孢菌素在人体皮下组织液中渗透的影响。
Influence of serum protein binding and mode of administration on penetration of five cephalosporins into subcutaneous tissue fluid in humans.
作者信息
Hoffstedt B, Walder M
出版信息
Antimicrob Agents Chemother. 1981 Dec;20(6):783-6. doi: 10.1128/AAC.20.6.783.
Abstract
The penetration of five cephalosporins into interstitial fluid was investigated by a new method employing cotton threads implanted subcutaneously. Penetration after short bolus injections, calculated as area under interstitial fluid level curve divided by area under serum level curve x 100, was 47.0% for cephradine, 30.6% for cefuroxime, 26.7% for cefotaxime, 24.6% for cefoxitin, and 9.6% for cefoperazone. There was an inverse correlation between the degree of penetration and serum protein binding with r = -0.97. The area under interstitial fluid level curves was the same whether the drugs were administered as short bolus injections or short time infusions.
摘要
采用皮下植入棉线的新方法研究了五种头孢菌素向组织间液的渗透情况。短时间推注后的渗透情况，以组织间液水平曲线下面积除以血清水平曲线下面积×100计算，头孢拉定为47.0%，头孢呋辛为30.6%，头孢噻肟为26.7%，头孢西丁为24.6%，头孢哌酮为9.6%。渗透程度与血清蛋白结合率之间呈负相关，r = -0.97。无论药物是短时间推注还是短时间输注，组织间液水平曲线下面积相同。
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