Comparative study on the interstitial passage of cefuroxime, cefoxitin, cefotaxime and cefoperazone in man by the suction skin blister method.

A comparative study was carried out on the concentration of cefuroxime, cefoxitin, cefotaxime and cefoperazone in serum and extravascular blister fluid. The results show that cefoperazone (which has the highest protein binding capacity) has a lower and slower extravascular penetration than the other cephalosporins examined.