Falconer J, Robinson J S
Aust J Exp Biol Med Sci. 1981 Oct;59(Pt 5):623-8. doi: 10.1038/icb.1981.55.
Somatomedin-like activity (SLA) was measured in serial samples of amniotic fluid and maternal plasma from Rhesus monkeys (Macaca mulatta) using the porcine costal cartilage disc bioassay. Samples of both amniotic fluid and maternal plasma gave dose response curves which were parallel to the human plasma standard. Concentrations of SLA were consistently lower in amniotic fluid (0.42 +/- 0.02, mean +/- S.E.M., units/ml, n = 33) than in maternal plasma (0.60 +/- 0.03 units/ml, n = 31). No significant changes in concentrations of SLA with gestational age were found during the period studied (90-170 days of pregnancy). The presence of SLA in amniotic fluid is consistent with the possibility that somatomedin plays a role in the control of foetal or placental growth in the primate.
使用猪肋软骨盘生物测定法，对恒河猴（猕猴）羊水和母体血浆的系列样本进行了类胰岛素生长因子活性（SLA）测定。羊水和母体血浆样本均给出了与人类血浆标准平行的剂量反应曲线。羊水中SLA的浓度（0.42±0.02，平均值±标准误，单位/毫升，n = 33）始终低于母体血浆中的浓度（0.60±0.03单位/毫升，n = 31）。在所研究的孕期（妊娠90 - 170天）内，未发现SLA浓度随胎龄有显著变化。羊水中存在SLA，这与类胰岛素生长因子在灵长类动物胎儿或胎盘生长控制中发挥作用的可能性相符。
