Zhou G P, Li T T, Chou K C
Biophys Chem. 1981 Nov;14(3):277-81. doi: 10.1016/0301-4622(81)85028-4.
The combination between enzymes and substrates occur only after their reacting groups are in juxtaposition with each other. This will greatly reduce the probability of their effective encounters. However, the results calculated with the finite elements method show that the reaction limits will not decrease substantially if van der Waal's forces and a reasonable flexibility during such a juxtaposition are taken into account.
酶与底物只有在它们的反应基团相互并列后才会发生结合。这将大大降低它们有效相遇的概率。然而，用有限元方法计算的结果表明，如果考虑范德华力以及在这种并列过程中的合理柔韧性，反应限度不会大幅降低。
