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[新生期暴露于免疫制剂的不同品系小鼠肿瘤发生抗性的变化]

[Changes in resistance to tumor development in various strains of mice exposed to immunologic agents during the neonatal period].

作者信息

Volegov A I

出版信息

Biull Eksp Biol Med. 1981 Dec;92(12):711-2.

PMID:7326422
Abstract

In the course of exposures to the immunological agents (BCG, complete Freund's adjuvant) during the postnatal period, the resistance to tumor development induced with chemical carcinogens was found to increase in C57BL/6 mice, particularly in BALB/c and random-bred ones; meanwhile in C3H/He mice it declined. At the same time C3H/He mice showed a decrease in the resistance to the development of spontaneous tumors of the mammary glands. The changes recorded correlated with those seen in the immunocompetent organs.

摘要

在出生后接触免疫制剂(卡介苗、完全弗氏佐剂)的过程中,发现C57BL/6小鼠,尤其是BALB/c小鼠和随机繁殖小鼠对化学致癌物诱导的肿瘤发生的抵抗力增强;与此同时,C3H/He小鼠的抵抗力下降。同时,C3H/He小鼠对乳腺自发肿瘤发生的抵抗力也有所降低。记录到的这些变化与免疫活性器官中观察到的变化相关。

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