McPhaul J J, Montgomery R
Clin Exp Immunol. 1981 Jun;44(3):560-6.
Seventeen patients found to have cryoimmunoglobulinaemia (CIG) while undergoing diagnostic renal biopsy and two patients with CIG without renal disease were studied. The cryoprecipitates (CP) from four of seven patients tested contained enhanced concentrations of autoantibodies: to vascular smooth muscle, autologous skeletal muscle, nuclear antigen and cardiac muscle. Antisera were made in rabbits against each of the 19 CP; six antisera contained antibodies to sarcolemma of skeletal muscle, nuclear antigen, elastin, reticulin, renal eluate and autologous kidney immune deposits respectively. Although one anti-CP antiserum bound to renal deposits, eight others tested on autologous renal biopsies did not. The data suggest that CP frequently may contain enhanced concentration of circulating autoantibodies and/or tissue antigens, possibly as immune complexes. In only one case was it possible to demonstrate that there was a common immunological identity between CP and renal Ig deposits.
对17例在进行诊断性肾活检时发现患有冷球蛋白血症（CIG）的患者以及2例无肾脏疾病的CIG患者进行了研究。在接受检测的7例患者中，有4例的冷沉淀物（CP）中自身抗体浓度升高：针对血管平滑肌、自体骨骼肌、核抗原和心肌的抗体。用兔制备了针对19种CP中每一种的抗血清；六种抗血清分别含有针对骨骼肌肌膜、核抗原、弹性蛋白、网状纤维、肾洗脱液和自体肾免疫沉积物的抗体。尽管一种抗CP抗血清与肾沉积物结合，但在自体肾活检中检测的其他八种抗血清未结合。数据表明，CP可能经常含有浓度升高的循环自身抗体和/或组织抗原，可能以免疫复合物的形式存在。仅在一例中能够证明CP与肾Ig沉积物之间存在共同的免疫学特征。
