Morré D J
Eur J Cell Biol. 1981 Dec;26(1):21-5.
Vesicles containing single lipoprotein particles were observed in the perisinusoidal cytoplasm of rat hepatocytes in the proximity of particle-containing rough-smooth endoplasmic reticulum transition elements. Single particle vesicles were observed also in stages interpreted as fusion with the plasma membrane. The putative smooth endoplasmic reticulum-derived vesicles were clearly different from the multiparticle secretory vesicles derived from the Golgi apparatus. The findings suggest the operation of two pathways of lipoprotein secretion in rat liver. One follows the orthodox smooth endoplasmic reticulum Golgi apparatus secretory vesicle plasma membrane export route. The second seems to proceed via smooth endoplasmic reticulum secretory vesicle plasma membrane in a manner that bypasses the Golgi apparatus.
在含有颗粒的粗面-滑面内质网过渡元件附近的大鼠肝细胞窦周细胞质中观察到含有单个脂蛋白颗粒的囊泡。在被解释为与质膜融合的阶段也观察到了单颗粒囊泡。推测的滑面内质网衍生的囊泡与源自高尔基体的多颗粒分泌囊泡明显不同。这些发现表明大鼠肝脏中脂蛋白分泌存在两条途径。一条遵循传统的滑面内质网-高尔基体-分泌囊泡-质膜的输出途径。第二条似乎以绕过高尔基体的方式通过滑面内质网-分泌囊泡-质膜进行。
