Antagonistic activity of galanthamine on constant infusion of pancuronium in rats.

The effect of galanthamine, an anticholinesterase having a tertiary ammonium group, on a constant infusion of pancuronium was studied in the rat tibialis anterior-sciatic nerve preparation. The results were compared with those previously obtained with neostigmine, pyridostigmine, and 4-aminopyridine. The antagonizing activity of galanthamine is similar to that of 4-aminopyridine and less than that of the other 2 anticholinesterases. The duration of galanthamine antagonism is similar to that of neostigmine and pyridostigmine but less than that of 4-aminopyridine.