Gorshinskaia I A, Grabovskova L L, Bronovitskaia Z G, Krichevskaia A A
Fiziol Zh SSSR Im I M Sechenova. 1981 Nov;67(11):1611-6.
One--day cold exposure decreases the monoamine oxidase type A activity by 52--54% (serotonin and noradrenaline substrates); the monoamine oxidase type B activity by 14%. Three--day cold exposure leaves the monoamine oxidase type B activity unchanged and decreases the monoamine oxidase type A activity by 29--32%; the enzyme of the latter type acquires the ability for deamination of glucosamine, putrescine and GABA. Under cold adaptation (45 days, 2 degrees C) the monoamine oxidase type A activity remains reduced as on the 3rd day, the type B activity decreases by 19%; enzyme substrate specificity does not change at all. Preliminary cold adaptation prevents alteration of the monoamine oxidase substrate specificity under hyperbaric oxygenation.
一天的冷暴露使A型单胺氧化酶活性降低52% - 54%(血清素和去甲肾上腺素底物);使B型单胺氧化酶活性降低14%。三天的冷暴露使B型单胺氧化酶活性保持不变,使A型单胺氧化酶活性降低29% - 32%;后一种类型的酶获得了对氨基葡萄糖、腐胺和γ-氨基丁酸的脱氨基能力。在冷适应(45天,2摄氏度)下,A型单胺氧化酶活性如第三天一样仍保持降低,B型活性降低19%;酶的底物特异性完全没有变化。预先冷适应可防止在高压氧合下A型单胺氧化酶底物特异性的改变。