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[适应寒冷以及同时暴露于寒冷和高压氧环境期间大脑中的单胺氧化酶活性]

[Monoamine oxidase activity in the brain during adaptation to cold and simultaneous exposure to cold and hyperbaric oxygenation].

作者信息

Gorshinskaia I A, Grabovskova L L, Bronovitskaia Z G, Krichevskaia A A

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1981 Nov;67(11):1611-6.

PMID:7327272
Abstract

One--day cold exposure decreases the monoamine oxidase type A activity by 52--54% (serotonin and noradrenaline substrates); the monoamine oxidase type B activity by 14%. Three--day cold exposure leaves the monoamine oxidase type B activity unchanged and decreases the monoamine oxidase type A activity by 29--32%; the enzyme of the latter type acquires the ability for deamination of glucosamine, putrescine and GABA. Under cold adaptation (45 days, 2 degrees C) the monoamine oxidase type A activity remains reduced as on the 3rd day, the type B activity decreases by 19%; enzyme substrate specificity does not change at all. Preliminary cold adaptation prevents alteration of the monoamine oxidase substrate specificity under hyperbaric oxygenation.

摘要

一天的冷暴露使A型单胺氧化酶活性降低52% - 54%(血清素和去甲肾上腺素底物);使B型单胺氧化酶活性降低14%。三天的冷暴露使B型单胺氧化酶活性保持不变,使A型单胺氧化酶活性降低29% - 32%;后一种类型的酶获得了对氨基葡萄糖、腐胺和γ-氨基丁酸的脱氨基能力。在冷适应(45天,2摄氏度)下,A型单胺氧化酶活性如第三天一样仍保持降低,B型活性降低19%;酶的底物特异性完全没有变化。预先冷适应可防止在高压氧合下A型单胺氧化酶底物特异性的改变。

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