McGrath B P, Matthews P G, Walter N M, Maydom B W, Johnston C I
Med J Aust. 1978 Oct 21;2(9):410-1. doi: 10.5694/j.1326-5377.1978.tb76817.x.
The effects of intravenously administered labetalol on blood pressure and pulse rate were examined in 17 patients with severe hypertension. Prompt and sustained falls in supine blood pressure and pulse rate occurred in ten patients (responders), but seven patients showed little or no change in either measurement (non-responders). Labetalol had a more marked effect on standing than on supine blood pressure. Only two of the responders, but all of the non-responders were concurrently receiving antihypertensive drugs. Plasma renin activity, plasma renin concentration and plasma angiotensin II concentration fell slightly over the one-hour period of observation in ten patients in whom serial measurements were made, but the changes were independent of the blood pressure response.
在17例重度高血压患者中研究了静脉注射拉贝洛尔对血压和脉搏率的影响。10例患者（反应者）仰卧位血压和脉搏率迅速且持续下降，但7例患者这两项测量指标几乎没有变化或无变化（无反应者）。拉贝洛尔对站立位血压的影响比对仰卧位血压的影响更显著。反应者中只有2例，而所有无反应者同时正在接受抗高血压药物治疗。在进行了系列测量的10例患者中，观察的1小时内血浆肾素活性、血浆肾素浓度和血浆血管紧张素II浓度略有下降，但这些变化与血压反应无关。
