关于二次生长的理论方程及其在海胆胚胎早期发育动力学中的应用。

A theoretical equation for diauxic growth and its application to the kinetics of the early development of the sea urchin embryo.

作者信息

Liquori A M, Monroy A, Parisi E, Tripiciano A

出版信息

Differentiation. 1981;20(2):174-5. doi: 10.1111/j.1432-0436.1981.tb01173.x.

DOI:10.1111/j.1432-0436.1981.tb01173.x

Abstract

The equation for diauxic growth is derived as a linear combination of two functions describing a slow and a fast rate of cell multiplication. The growth curve displays the typical biphasic shape, containing two sigmoidal branches. The curve fits very satisfactorily experimental data describing the increase of cell number in developing sea urchin embryos as a function of time, thus suggesting the presence of diauxia in this system. The hypothesis is formulated that diauxia in sea urchin embryos is the expression of two distinct metabolic pathways that result in a slow and a fast division process.

摘要

双相生长方程是由两个描述细胞增殖快慢速率的函数的线性组合推导得出的。生长曲线呈现出典型的双相形状，包含两个S形分支。该曲线非常令人满意地拟合了描述发育中的海胆胚胎细胞数量随时间增加的实验数据，从而表明该系统中存在双相生长现象。提出的假设是，海胆胚胎中的双相生长是两种不同代谢途径的表现，这两种途径导致了缓慢和快速的分裂过程。