Ciliberto A, Tyson J J
Dipartimento di Biologia Animale e Genetica, Università degli studi di Firenze, Italy.
Bull Math Biol. 2000 Jan;62(1):37-59. doi: 10.1006/bulm.1999.0129.
In Xenopus and Drosophila, the nucleocytoplasmic ratio controls many aspects of cell-cycle remodeling during the transitory period that leads from fast and synchronous cell divisions of early development to the slow, carefully regulated growth and divisions of somatic cells. After the fifth cleavage in sea urchin embryos, there are four populations of differently sized blastomeres, whose interdivision times are inversely related to size. The inverse relation suggests nucleocytoplasmic control of cell division during sea urchin development as well. To investigate this possibility, we developed a mathematical model based on molecular interactions underlying early embryonic cell-cycle control. Introducing the nucleocytoplasmic ratio explicitly into the molecular mechanism, we are able to reproduce many physiological features of sea urchin development.
在非洲爪蟾和果蝇中，核质比在从早期发育的快速同步细胞分裂到体细胞缓慢且受到精细调控的生长与分裂的过渡阶段，控制着细胞周期重塑的多个方面。海胆胚胎在第五次卵裂后，存在四种不同大小的卵裂球群体，它们的分裂间期与大小呈反比关系。这种反比关系表明，在海胆发育过程中细胞分裂也受到核质控制。为了探究这种可能性，我们基于早期胚胎细胞周期控制的分子相互作用建立了一个数学模型。通过将核质比明确引入分子机制，我们能够重现海胆发育的许多生理特征。
