Fukuda K, Matsushita H, Sakabe H, Takemoto K
Gan. 1981 Oct;72(5):655-64.
The carcinogenicity of benzyl chloride (BYC), benzal chloride (BAC), benzotrichloride (BTC) and benzoyl chloride (BOC), which were suspected as causative agents of lung cancer and maxillary malignant lymphoma of workers employed in factories producing BOC, was examined by skin applications in female ICR mice. After rather high dose exposure, BTC exhibited leukemogenic and pulmonary tumorigenic activities as well as potent dermal carcinogenic activity. After administration of the chemicals at the dose of 2.3 microliter/animal, twice a week for 50 weeks, BTC induced 68% incidence of skin cancers and 58% incidence of pulmonary tumors (including 10% of lung carcinomas) within 399 days. Incidence of skin cancers was 58% for BAC, 15% for BYC and 10% for BOC within 560 days. Considering the extent of possible exposure of the workers to these chemicals in the working environment and the carcinogenic potency of the chemicals tested, it can be concluded that BTC was very probably responsible for causing the cancers seen int he workers employed in manufacturing BOC.
对苄基氯（BYC）、苯甲醛氯（BAC）、三氯甲苯（BTC）和苯甲酰氯（BOC）的致癌性进行了研究，它们被怀疑是生产BOC工厂工人肺癌和上颌恶性淋巴瘤的致病因素，通过对雌性ICR小鼠进行皮肤涂抹来检测。在相当高剂量暴露后，BTC表现出致白血病和肺肿瘤发生活性以及强效的皮肤致癌活性。以2.3微升/只动物的剂量，每周两次，持续50周给予这些化学物质后，BTC在399天内诱发了68%的皮肤癌发病率和58%的肺肿瘤发病率（包括10%的肺癌）。在560天内，BAC的皮肤癌发病率为58%，BYC为15%，BOC为10%。考虑到工人在工作环境中可能接触这些化学物质的程度以及所测试化学物质的致癌效力，可以得出结论，BTC很可能是导致生产BOC工厂工人患癌症的原因。
