Abe H, Konishi Y, Arichi S
Nihon Yakurigaku Zasshi. 1981 Nov;78(5):465-70.
Effects of a "kanpo" -prescription; Sairei-Toh on the antigranulomatous action of glucocorticoid were investigated using male rats. Sairei-Toh increased the activity of the antigranulomatous action of dexamethasone although treatment with only Sairei-Toh showed no significant antigranulomatous action, as compared with the controls. The granuloma formation was reduced by administration of dexamethasone 0.5 mg/kg/day and Sairei-Toh for 4 days to almost the same extent as seen with 1.5 mg/kg/day of dexamethasone. The concomitant administration of Sairei-Toh and dexamethasone slightly inhibited the increase in serum triglycerides as induced by dexamethasone but did not alter serum cholesterol levels. There was no apparent difference in body, adrenal and thymus weights between the rats treated with dexamethasone in combinations with Sairei-Toh and those treated with only dexamethasone.
使用雄性大鼠研究了一种汉方制剂柴苓汤对糖皮质激素抗肉芽肿作用的影响。与对照组相比，虽然单独使用柴苓汤治疗未显示出显著的抗肉芽肿作用，但柴苓汤增强了地塞米松的抗肉芽肿作用活性。给予0.5mg/kg/天地塞米松和柴苓汤4天，肉芽肿形成减少到与给予1.5mg/kg/天地塞米松几乎相同的程度。柴苓汤与地塞米松联合给药略微抑制了地塞米松诱导的血清甘油三酯升高，但未改变血清胆固醇水平。联合使用地塞米松和柴苓汤治疗的大鼠与仅用地塞米松治疗的大鼠在体重、肾上腺重量和胸腺重量方面没有明显差异。
