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将乙二醛酶II基因(HAGH)定位于人类第16号染色体。

Assignment of the glyoxalase II gene (HAGH) to human chromosome 16.

作者信息

Honey N K, Shows T B

出版信息

Hum Genet. 1981;58(4):358-61. doi: 10.1007/BF00282815.

DOI:10.1007/BF00282815
PMID:7327557
Abstract

The human and rodent forms of glyoxalase II (Hydroxyacylglutathione hydrolase, HAGH) can readily be separated by starch gel electrophoretic procedures. Fifty-one human-rodent somatic cell hybrid clones were examined for their human HAGH and for human enzyme markers whose genes are encoded on each autosome and the X chromosome. Sixteen clones were also examined for their human karyotypes. Human glyoxalase II segregated only with chromosome 16, demonstrating that the gene is located on this chromosome.

摘要

乙二醛酶II(羟酰谷胱甘肽水解酶,HAGH)的人类和啮齿动物形式可以很容易地通过淀粉凝胶电泳程序分离。对51个人类-啮齿动物体细胞杂交克隆进行了检测,分析它们是否含有人类HAGH以及其基因定位于各常染色体和X染色体上的人类酶标记。还对16个克隆进行了人类核型分析。人类乙二醛酶II仅与16号染色体分离,表明该基因位于这条染色体上。

相似文献

1
Assignment of the glyoxalase II gene (HAGH) to human chromosome 16.将乙二醛酶II基因(HAGH)定位于人类第16号染色体。
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引用本文的文献

1
The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.乙二醛酶系统:对生物生命基本代谢途径进行功能表征的新进展。
Biochem J. 1990 Jul 1;269(1):1-11. doi: 10.1042/bj2690001.

本文引用的文献

1
Genetic polymorphism of human erythrocyte glyoxalase II.人红细胞乙二醛酶II的基因多态性
Am J Hum Genet. 1980 Sep;32(5):690-4.
2
Purification and characterization of mouse liver glyoxalase II.小鼠肝脏乙二醛酶II的纯化与特性分析
Biochim Biophys Acta. 1980 Jan 11;611(1):168-73. doi: 10.1016/0005-2744(80)90052-2.
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Erythrocyte glyoxalase II deficiency with coincidental hereditary elliptocytosis.
Blood. 1970 Dec;36(6):797-808.
4
Starch-gel electrophoresis of four enzymes from human red blood cells: glyceraldehyde-3-phosphate dehydrogenase, fructoaldolase, glyoxalase II and sorbitol dehydrogenase.
Ann Hum Genet. 1972 Apr;35(4):477-84. doi: 10.1111/j.1469-1809.1957.tb01873.x.
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Proceedings: Synteny relationships of beta-D-N-acetylhexosaminidase A and B in somatic cell hybrids.
Cytogenet Cell Genet. 1974;13(1):111-6. doi: 10.1159/000130250.
6
Purification and characterization of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from human liver.人肝脏中S-2-羟酰谷胱甘肽水解酶(乙二醛酶II)的纯化与特性分析
Biochemistry. 1973 Sep 25;12(20):3944-51. doi: 10.1021/bi00744a025.
7
Genetics of human-mouse somatic cell hybrids: linkage of human genes for lactate dehydrogenase-A and esterase-A 4 .人-小鼠体细胞杂种的遗传学:人类乳酸脱氢酶-A和酯酶-A 4基因的连锁
Proc Natl Acad Sci U S A. 1972 Feb;69(2):348-52. doi: 10.1073/pnas.69.2.348.
8
Human X-Linked genes regionally mapped utilizing X-autosome translocations and somatic cell hybrids.利用X-常染色体易位和体细胞杂种对人类X连锁基因进行区域定位。
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2125-9. doi: 10.1073/pnas.72.6.2125.
9
Improved techniques for the induction of mammalian cell hybridization by polyethylene glycol.通过聚乙二醇诱导哺乳动物细胞杂交的改良技术。
Somatic Cell Genet. 1976 Mar;2(2):165-76. doi: 10.1007/BF01542629.
10
Expression of human hexosaminidase-A phenotype depends on genes assigned to chromosomes 5 and 15.人类己糖胺酶 - A 表型的表达取决于定位于 5 号和 15 号染色体上的基因。
Cytogenet Cell Genet. 1976;16(1-5):192-6. doi: 10.1159/000130588.