Ratge D, Knoll E, Diener U, Wisser H
J Clin Chem Clin Biochem. 1981 Jul;19(7):479-84.
The daily time course of urinary catecholamine excretion was determined for hyperactivity of the sympathoadrenal system (3 phaeochromocytomas, 1 neuroblastoma), disturbed adrenal function (M. Addison and partial adrenal insufficiency), bilateral adrenalectomy (one patient), in 8 healthy patients receiving dexamethasone, and in a control group. All groups showed a circadian rhythm of catecholamine excretion. In the patients with phaeochromocytoma, the excretion of catecholamines and vanilmandelic acid showed a shift of phase compared with the control group. In patients with hyperfunction of the sympathoadrenal system, catecholamines and vanilmandelic acid fluctuated with similar amplitudes, whereas in healthy patients vanilmandelic acid and dopamine showed much smaller fluctuations of concentration than adrenaline and noradrenaline.
测定了交感肾上腺系统功能亢进（3例嗜铬细胞瘤、1例神经母细胞瘤）、肾上腺功能紊乱（艾迪生病和部分肾上腺功能不全）、双侧肾上腺切除术（1例患者）、8例接受地塞米松的健康患者以及对照组尿儿茶酚胺排泄的每日时间进程。所有组均显示儿茶酚胺排泄的昼夜节律。嗜铬细胞瘤患者中，儿茶酚胺和香草扁桃酸的排泄与对照组相比出现相位偏移。在交感肾上腺系统功能亢进的患者中，儿茶酚胺和香草扁桃酸以相似幅度波动，而在健康患者中，香草扁桃酸和多巴胺浓度的波动幅度远小于肾上腺素和去甲肾上腺素。
