作为潜在抗肿瘤药物的N*-N*-S*三齿配体体系。
N*-N*-S* tridentate ligand system as potential antitumor agents.
作者信息
Antonini I, Claudi F, Cristalli G, Franchetti P, Grifantini M, Martelli S
出版信息
J Med Chem. 1981 Oct;24(10):1181-4. doi: 10.1021/jm00142a012.
PMID:7328579
Abstract
Compounds containing an N*-N*-S* tridentate ligand were synthesized and tested for antitumor activity against P-388 lymphocytic leukemia in mice. Of these, only 2,2'-bipyridyl-6-carbothioamide (1a) showed antitumor activity at relatively high dosage levels. Compound 1a was also evaluated against L-1210 and S180 cells in culture and found to have significant activity.
摘要
合成了含有N*-N*-S*三齿配体的化合物，并对其在小鼠体内抗P - 388淋巴细胞白血病的抗肿瘤活性进行了测试。其中，只有2,2'-联吡啶-6-碳硫酰胺（1a）在相对高剂量水平下显示出抗肿瘤活性。还对化合物1a在培养物中针对L - 1210和S180细胞进行了评估，发现其具有显著活性。
相似文献
1
N*-N*-S* tridentate ligand system as potential antitumor agents.作为潜在抗肿瘤药物的N*-N*-S*三齿配体体系。
J Med Chem. 1981 Oct;24(10):1181-4. doi: 10.1021/jm00142a012.
2
2,2'-Bipyridyl-6-carbothioamide derivatives as potential antitumor agents.2,2'-联吡啶-6-碳硫酰胺衍生物作为潜在的抗肿瘤药物。
Farmaco Sci. 1986 May;41(5):346-54. doi: 10.1002/chin.198646232.
3
2,2'-Bipyridyl-6-carboxamidoximes with potential antitumor and antimicrobial properties.
Farmaco Sci. 1986 Jul;41(7):499-507. doi: 10.1002/chin.198650243.
4
Synthesis, spectroscopic, mutagenic, and cytotoxicity studies of some mixed-ligand platinum(II) complexes of 2,2'-bipyridine and amino acids.2,2'-联吡啶与氨基酸的一些混合配体铂（II）配合物的合成、光谱、诱变和细胞毒性研究
J Inorg Biochem. 1987 Sep;31(1):57-64. doi: 10.1016/0162-0134(87)85005-5.
5
Some mixed-ligand palladium(II) complexes of 2,2'-bipyridine and amino acids as potential anticancer agents.
J Inorg Biochem. 1985 Nov;25(3):207-15. doi: 10.1016/0162-0134(85)80014-3.
6
Antitumor activity of 2,2'-bipyridyl-6-carbothioamide: a ribonucleotide reductase inhibitor.2,2'-联吡啶-6-碳硫酰胺的抗肿瘤活性：一种核糖核苷酸还原酶抑制剂
Gen Pharmacol. 1997 Nov;29(5):701-6. doi: 10.1016/s0306-3623(97)00011-6.
7
Isolation of two cellular lines resistant to ribonucleotide reductase inhibitors to investigate the inhibitory activity of 2,2'-bipyridyl-6-carbothioamide.
Anticancer Drugs. 1990 Dec;1(2):171-7. doi: 10.1097/00001813-199012000-00009.
8
[Synthesis of bis-(pirydylmethyl)amines].[双（吡啶基甲基）胺的合成]
Acta Pol Pharm. 1976;33(3):307-10.
9
Biological properties of dipyridyl sulphides and related compounds.联吡啶硫醚及相关化合物的生物学特性。
Arch Immunol Ther Exp (Warsz). 1985;33(2):331-8.
10
[Antitumor platinum(II) complexes with substituted 2-aminomethylpyridine ligands].[带有取代的2-氨基甲基吡啶配体的抗肿瘤铂（II）配合物]
Arch Pharm (Weinheim). 1991 Oct;324(10):779-84.
引用本文的文献
1
Characterization of a selective, iron-chelating antifungal compound that disrupts fungal metabolism and synergizes with fluconazole.一种选择性、螯合铁的抗真菌化合物的特性研究，该化合物能破坏真菌代谢并与氟康唑协同作用。
Microbiol Spectr. 2024 Feb 6;12(2):e0259423. doi: 10.1128/spectrum.02594-23. Epub 2024 Jan 17.
2
Insights into the role of the cobalt(III)-thiosemicarbazone complex as a potential inhibitor of the Chikungunya virus nsP4.钴（III）-硫代半卡巴腙配合物作为潜在的基孔肯雅病毒 nsP4 抑制剂的作用研究。
J Biol Inorg Chem. 2023 Feb;28(1):101-115. doi: 10.1007/s00775-022-01974-z. Epub 2022 Dec 9.
3
Implications and problems in analysing cytotoxic activity of hydroxyurea in combination with a potential inhibitor of ribonucleotide reductase.
Cancer Chemother Pharmacol. 1990;26(5):345-51. doi: 10.1007/BF02897291.
Zotero 插件