Tansy M F, Kendall F M, Fantasia J, Landin W E, Oberly R, Sherman W
J Toxicol Environ Health. 1981 Jul-Aug;8(1-2):71-88. doi: 10.1080/15287398109530051.
Acute inhalation experiments were conducted to determine 24-h LC50 values for adult Sprague-Dawley rats of both sexes exposed to vapors of methyl mercaptan and other reduced-S compounds for 4 h periods. Using calculated gas concentrations, the following LC50 value for each gas and combination was determined: metyhl mercaptan, 675 ppm; dimethyl sulfide, 40,250 ppm; dimethyl disulfide, 805 ppm; hydrogen sulfide, 444 ppm; and an equimolar mixture of methyl mercaptan, dimethyl sulfide, and dimethyl disulfide, 550 ppm. The effects of body and tissue weights, gross metabolic performance, O2 consumption, systolic blood pressure, various blood parameters, and intestinal transit time associated with 3-mo exposures of young adult male rats to chemically verified concentrations of 2, 17, and 57 ppm methyl mercaptan vapor are summarized in this report. No mortality was experienced by any group. Histopathological findings were essentially nil except for microscopic suggestions of liver damage. The most readily apparent phenomenon was the decrease in body weight. Average values of terminal body weights for all exposed groups were lower than that for the sham control group. This difference was significant in the 57 ppm group and followed a statistically significant dose-related trend.
进行急性吸入实验以确定成年雄性和雌性斯普拉格-道利大鼠在暴露于甲硫醇和其他含硫化合物蒸汽4小时的情况下的24小时半数致死浓度（LC50）值。利用计算出的气体浓度，确定了每种气体及其混合物的LC50值如下：甲硫醇，675 ppm；二甲基硫醚，40,250 ppm；二甲基二硫醚，805 ppm；硫化氢，444 ppm；以及甲硫醇、二甲基硫醚和二甲基二硫醚的等摩尔混合物，550 ppm。本报告总结了年轻成年雄性大鼠在3个月内暴露于经化学验证的2、17和57 ppm甲硫醇蒸汽浓度下，其体重和组织重量、总体代谢性能、氧气消耗、收缩压、各种血液参数以及肠道转运时间的影响。任何组均未出现死亡情况。除了肝脏损伤的微观迹象外，组织病理学检查结果基本为零。最明显的现象是体重下降。所有暴露组的终末体重平均值均低于假对照组。这种差异在57 ppm组中具有统计学意义，并呈现出统计学上显著的剂量相关趋势。
