Clinic for Integrative Dentistry, Munich, Germany.
Compartment of Immunology and Allergology, Institute for Medical Diagnostics, Berlin, Germany.
Int J Gen Med. 2015 Mar 10;8:109-18. doi: 10.2147/IJGM.S77693. eCollection 2015.
Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether. In this retrospective study, we evaluated the ex vivo immune response of peripheral blood mononuclear cells to sulfur compounds in 354 patients with systemic diseases. These systemic findings are correlated with semiquantitative values of a VSC indicator applied directly on endodontically treated teeth. Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells. The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.
经根管治疗的牙齿中持续存在的微生物会产生挥发性硫化合物 (VSC)，如甲硫醇、硫化氢和硫醚。在这项回顾性研究中，我们评估了 354 名患有系统性疾病患者的外周血单核细胞对硫化合物的体外免疫反应。这些系统发现与直接应用于根管治疗牙齿的 VSC 指示剂的半定量值相关。数据阐明了 VSC 在免疫性疾病患者中的作用，以及像这里介绍的 VSC 指示剂这样的椅旁半定量检测在与外周血单核细胞中 IFNg 和 IL-10 致敏相关中的作用。体外刺激细胞因子与根管衍生的硫成分之间的关联得到了支持，因为在相应牙齿拔除后 3-8 个月，干扰素 γ 和/或白细胞介素 10 阳性致敏患者的数量显著下降。
