Mann D M, Yates P O
Mech Ageing Dev. 1981 Dec;17(4):395-401. doi: 10.1016/0047-6374(81)90056-7.
Nerve cell nucleolar volume in reduced, in senile dementia of Alzheimer type, by 15 - 25% in nerve cells not containing neurofibrillary tangles and by over 35% in those which do contain such changes, in a wide variety of brain regions, when compared to similar cells from non-demented control cases, suggesting that interference with production of proteins may be an early consequence of the pathogenic process. The extent to which nucleolar volume is decreased in the non-tangle-bearing cells is related to frequencies of both neurofibrillary tangle and senile-plaque formation within that region, but the reduction in volume in the tangle-bearing cells correlated with neurofibrillary changes only. It seems, therefore, that the severity with which the dementing process affects an area of brain is initially shown by alterations in cell metabolism, which may invoke reductions in protein synthesis in non-tangle-bearing cells, and is later marked by the proportion of these affected cells which go to form neurofibrillary tangles. Changes in nerve cell function do not seem to be as well indicated by the density of senile plaques within that area.
在阿尔茨海默型老年痴呆症中，与非痴呆对照病例的相似细胞相比，多种脑区中不含神经原纤维缠结的神经细胞核仁体积减少了15% - 25%，而含有此类变化的神经细胞核仁体积减少超过35%，这表明对蛋白质产生的干扰可能是致病过程的早期后果。在无缠结细胞中核仁体积减少的程度与该区域神经原纤维缠结和老年斑形成的频率均有关，但有缠结细胞中体积的减少仅与神经原纤维变化相关。因此，痴呆过程影响脑区的严重程度最初表现为细胞代谢的改变，这可能导致无缠结细胞中蛋白质合成减少，随后表现为这些受影响细胞形成神经原纤维缠结的比例。该区域内老年斑的密度似乎并不能很好地表明神经细胞功能的变化。
