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A comparison of the inhibition of bovine and murine leukemia dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-X-phenyl)-s-triazines.

作者信息

Guo Z R, Dietrich S W, Hansch C, Dolnick B J, Bertino J R

出版信息

Mol Pharmacol. 1981 Nov;20(3):649-56.

PMID:7329407
Abstract
摘要

相似文献

1
A comparison of the inhibition of bovine and murine leukemia dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-X-phenyl)-s-triazines.
Mol Pharmacol. 1981 Nov;20(3):649-56.
2
[Comparison of inhibitory effects of triazines on dihydrofolate reductase isolated from murine leukemia cells with the inhibition of growth of cells in culture].[三嗪类化合物对从鼠白血病细胞中分离出的二氢叶酸还原酶的抑制作用与对培养细胞生长的抑制作用的比较]
Yao Xue Xue Bao. 1983 Feb;18(2):125-9.
3
Comparison of triazines as inhibitors of L1210 dihydrofolate reductase and of L1210 cells sensitive and resistant to methotrexate.三嗪类化合物作为L1210二氢叶酸还原酶抑制剂以及对甲氨蝶呤敏感和耐药的L1210细胞的比较。
Cancer Res. 1986 Feb;46(2):744-56.
4
Inhibition of bovine and rat liver dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(4-substituted-phenyl)-s-triazines.4,6-二氨基-1,2-二氢-2,2-二甲基-1-(4-取代苯基)-均三嗪对牛和大鼠肝脏二氢叶酸还原酶的抑制作用
J Med Chem. 1981 May;24(5):544-9. doi: 10.1021/jm00137a013.
5
Inhibition of dihydrofolate reductase. 3. 4.6-Diamino-1,2-dihydro-2,2-dimethyl-1-(2-substituted-phenyl)-s-triazine inhibition of bovine liver and mouse tumor enzymes.二氢叶酸还原酶的抑制作用。3. 4,6-二氨基-1,2-二氢-2,2-二甲基-1-(2-取代苯基)-均三嗪对牛肝和小鼠肿瘤酶的抑制作用。
J Med Chem. 1980 Nov;23(11):1248-51. doi: 10.1021/jm00185a022.
6
Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis.4,6-二氨基-1,2-二氢-2,2-二甲基-1-(取代苯基)-s-三嗪对人二氢叶酸还原酶的抑制作用。定量构效关系分析。
J Med Chem. 1984 Feb;27(2):144-9. doi: 10.1021/jm00368a007.
7
Comparison of quantitative structure-activity relationships of the inhibition of leukemia cells in culture with the inhibition of dihydrofolate reductase from leukemia cells and other cell types.
J Med Chem. 1982 Feb;25(2):153-6. doi: 10.1021/jm00344a012.
8
Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines.4,6-二氨基-1,2-二氢-2,2-二甲基-1-(X-苯基)-均三嗪对卡氏肺孢子虫二氢叶酸还原酶抑制作用的定量构效关系
J Med Chem. 1995 Mar 17;38(6):967-72. doi: 10.1021/jm00006a016.
9
Irreversible enzyme inhibitors. 196. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine and bearing a terminal phenyl sulfonate group.不可逆酶抑制剂。196. 源自1-(4-苄氧基-3-氯苯基)-4,6-二氨基-1,2-二氢-2,2-二甲基-s-三嗪并带有末端苯磺酸盐基团的二氢叶酸还原酶的活性位点导向不可逆抑制剂。
J Med Chem. 1972 Sep;15(9):945-7. doi: 10.1021/jm00279a017.
10
Irreversible enzyme inhibitors. 197. Water-soluble reversible inhibitors of dihydrofolate reductase with potent antitumor activity derived from 4, 6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine.
J Med Chem. 1973 Mar;16(3):209-14. doi: 10.1021/jm00261a009.

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Recombinant bovine dihydrofolate reductase produced by mutagenesis and nested PCR of murine dihydrofolate reductase cDNA.通过对小鼠二氢叶酸还原酶cDNA进行诱变和巢式PCR产生的重组牛二氢叶酸还原酶。
Protein Expr Purif. 2008 Nov;62(1):104-10. doi: 10.1016/j.pep.2008.07.001. Epub 2008 Jul 17.