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Inhibition of bovine and rat liver dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(4-substituted-phenyl)-s-triazines.

作者信息

Hansch C, Dietrich S W, Fukunaga J Y

出版信息

J Med Chem. 1981 May;24(5):544-9. doi: 10.1021/jm00137a013.

DOI:10.1021/jm00137a013
PMID:7241512
Abstract
摘要

相似文献

1
Inhibition of bovine and rat liver dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(4-substituted-phenyl)-s-triazines.4,6-二氨基-1,2-二氢-2,2-二甲基-1-(4-取代苯基)-均三嗪对牛和大鼠肝脏二氢叶酸还原酶的抑制作用
J Med Chem. 1981 May;24(5):544-9. doi: 10.1021/jm00137a013.
2
A comparison of the inhibition of bovine and murine leukemia dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-X-phenyl)-s-triazines.
Mol Pharmacol. 1981 Nov;20(3):649-56.
3
Inhibition of dihydrofolate reductase. 3. 4.6-Diamino-1,2-dihydro-2,2-dimethyl-1-(2-substituted-phenyl)-s-triazine inhibition of bovine liver and mouse tumor enzymes.二氢叶酸还原酶的抑制作用。3. 4,6-二氨基-1,2-二氢-2,2-二甲基-1-(2-取代苯基)-均三嗪对牛肝和小鼠肿瘤酶的抑制作用。
J Med Chem. 1980 Nov;23(11):1248-51. doi: 10.1021/jm00185a022.
4
Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis.4,6-二氨基-1,2-二氢-2,2-二甲基-1-(取代苯基)-s-三嗪对人二氢叶酸还原酶的抑制作用。定量构效关系分析。
J Med Chem. 1984 Feb;27(2):144-9. doi: 10.1021/jm00368a007.
5
Irreversible enzyme inhibitors. CLXXVII. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(phenylalkylphenyl)-s-triazines. II.不可逆酶抑制剂。CLXXVII。源自4,6 - 二氨基 - 1,2 - 二氢 - 2,2 - 二甲基 - 1 -（苯基烷基苯基）-s-三嗪的二氢叶酸还原酶的活性位点导向不可逆抑制剂。II。
J Med Chem. 1970 Nov;13(6):1154-60. doi: 10.1021/jm00300a030.
6
Irreversible enzyme inhibitors. 196. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine and bearing a terminal phenyl sulfonate group.不可逆酶抑制剂。196. 源自1-(4-苄氧基-3-氯苯基)-4,6-二氨基-1,2-二氢-2,2-二甲基-s-三嗪并带有末端苯磺酸盐基团的二氢叶酸还原酶的活性位点导向不可逆抑制剂。
J Med Chem. 1972 Sep;15(9):945-7. doi: 10.1021/jm00279a017.
7
Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines.4,6-二氨基-1,2-二氢-2,2-二甲基-1-(X-苯基)-均三嗪对卡氏肺孢子虫二氢叶酸还原酶抑制作用的定量构效关系
J Med Chem. 1995 Mar 17;38(6):967-72. doi: 10.1021/jm00006a016.
8
Irreversible enzyme inhibitors. CV. Differential irreversible inhibition of vertebrate dihydrofolic reductases by derivatives of 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazines substituted with a terminal sulfonyl fluoride.
J Med Chem. 1967 Nov;10(6):1113-22. doi: 10.1021/jm00318a029.
9
Irreversible enzyme inhibitors. CLXXVI. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine by ether bridging to a terminal sulfonyl fluoride.不可逆酶抑制剂。CLXXVI. 通过醚桥连至末端磺酰氟由4,6-二氨基-1,2-二氢-2,2-二甲基-1-苯基-s-三嗪衍生而来的二氢叶酸还原酶的活性位点导向不可逆抑制剂。
J Med Chem. 1970 Nov;13(6):1149-54. doi: 10.1021/jm00300a029.
10
Irreversible enzyme inhibitors. 197. Water-soluble reversible inhibitors of dihydrofolate reductase with potent antitumor activity derived from 4, 6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine.
J Med Chem. 1973 Mar;16(3):209-14. doi: 10.1021/jm00261a009.

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