美西律在人体血液和母乳中的情况。
Mexiletine in human blood and breast milk.
作者信息
Lewis A M, Patel L, Johnston A, Turner P
出版信息
Postgrad Med J. 1981 Sep;57(671):546-7. doi: 10.1136/pgmj.57.671.546.
Abstract
Twelve paired samples of breast milk and blood were obtained, between the 2nd and 5th days after she had given birth, from a 30-year-old woman who was a 8-hourly propranolol (20 mg) and mexiletine (200 mg). Propranolol was detected in 9 of the samples of blood and in only 4 of the milk samples. Mexiletine was measurable in all samples, and the milk : plasma ratio varied between 0.79 and 1.89 with a mean of 1.45. However, the large volume of distribution of mexiletine makes it unlikely that the small dose of the drug received from the milk would be detrimental to the health of infants.
摘要
在一名30岁女性分娩后的第2天至第5天期间，采集了12对母乳和血液样本。该女性每8小时服用普萘洛尔（20毫克）和美西律（200毫克）。在9份血液样本中检测到了普萘洛尔，而在母乳样本中仅检测到4份。所有样本中均可检测到美西律，母乳与血浆的比值在0.79至1.89之间，平均为1.45。然而，美西律的分布容积较大，因此婴儿从母乳中摄入的小剂量药物不太可能对其健康有害。
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本文引用的文献
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