Bauer J H, Pape B, Zajicek J, Groshong T
Am J Cardiol. 1979 Apr;43(4):860-2. doi: 10.1016/0002-9149(79)90090-0.
To assess the problem of continuing propranolol therapy in a breast-feeding mother, studies were performed to determine simultaneously plasma and breast milk concentrations of propranolol after single dose (40 mg) and continuous dose (40 mg 4 times daily) treatment with this drug. Breast milk and plasma concentrations of propranolol peaked between 2 and 3 hours after dosing. Propranolol concentrations in breast milk were less than 40 and 64 percent, respectively, of peak plasma propranolol concentrations after single dose and continuous dose administration. It was estimated that the maximal cumulative propranolol load to this breast-feeding infant, consuming 500 ml of whole milk, when the mother received 40 mg of propranolol 4 times daily would be 21 microgram/24 hours. This dose is considerably less than the usual therapeutic dose of propranolol for infants.
为评估哺乳期母亲继续使用普萘洛尔治疗的问题，进行了多项研究，以确定单次给药（40毫克）和连续给药（每日4次，每次40毫克）后普萘洛尔在血浆和母乳中的浓度。给药后2至3小时，母乳和血浆中普萘洛尔浓度达到峰值。单次给药和连续给药后，母乳中普萘洛尔浓度分别低于血浆中普萘洛尔峰值浓度的40%和64%。据估计，当母亲每日4次服用40毫克普萘洛尔时，食用500毫升全脂牛奶的该哺乳期婴儿最大累积普萘洛尔摄入量为21微克/24小时。该剂量远低于婴儿普萘洛尔的常用治疗剂量。
