Kischer C W, Brody G S
Scan Electron Microsc. 1981(Pt 3):371-6.
The collagen nodule is the structural unit of all hypertrophic scars in keloids. It is never found in the fully mature scars. A study of the fine structure of the nodule might reflect its origin, and, hence, origin of the hypertrophic scar and keloid. Nodules are composed of a marked increase of unidirectional collagen fibrils aligned in a highly stressed orientation. There is also a marked increase in the number of fibroblasts. Few microvessels appear within the nodule; rather, they remain peripheral and encompass the main body of the nodule as a net. There is a heavier concentration of microvessels (3-13 micrometer in diameter) at the terminal ends, many of which are occluded. The occlusion appears due principally to an apparent increase in the number of endothelial cells. The character of the nodule and its relationship with a peripheral semioccluded microvascular network suggests an origin of the hypertrophic scar and keloid to be related to revascularization of a deep wound.
胶原结节是所有肥厚性瘢痕和瘢痕疙瘩的结构单位。在完全成熟的瘢痕中从未发现过。对结节精细结构的研究可能反映其起源，进而反映肥厚性瘢痕和瘢痕疙瘩的起源。结节由单向排列的胶原纤维显著增加组成，这些纤维以高应力方向排列。成纤维细胞数量也显著增加。结节内微血管很少；相反，它们位于周边，像网一样围绕着结节主体。在末端微血管浓度更高（直径3 - 13微米），其中许多被阻塞。阻塞主要是由于内皮细胞数量明显增加所致。结节的特征及其与周边半阻塞微血管网络的关系表明，肥厚性瘢痕和瘢痕疙瘩的起源与深部伤口再血管化有关。
