Hunter J A, Finlay J B
Br J Surg. 1976 Oct;63(10):826-30. doi: 10.1002/bjs.1800631024.
The fibrous architecture of 5 normal human scars between 1 week and 1 year old and 4 keloid scars has been studied by scanning electron microscopy. In normal wounds, significant changes in fibril and fibre orientations and mode of aggregation take place as the scars mature, indicating that remodelling carries on for many months. There are also major differences between the edge and centre of the wound. These changes can be related to the stresses placed on the fibroblasts which have responded by laying down collagen aligned in such a way as to resist these forces. It is suggested that keloid fibroblasts may lack this ability to respond appropriately to orientational stress.
通过扫描电子显微镜研究了5个1周龄至1岁的正常人类瘢痕和4个瘢痕疙瘩的纤维结构。在正常伤口中，随着瘢痕成熟，原纤维和纤维的取向以及聚集方式会发生显著变化，这表明重塑会持续数月。伤口边缘和中心之间也存在重大差异。这些变化可能与施加在成纤维细胞上的应力有关，成纤维细胞通过沉积排列方式能抵抗这些力的胶原蛋白做出反应。有人提出，瘢痕疙瘩成纤维细胞可能缺乏对取向应力做出适当反应的能力。
