静脉注射沙丁胺醇与氨茶碱治疗哮喘：寻找协同作用
Intravenous salbutamol and aminophylline in asthma: a search for synergy.
作者信息
Handslip P D, Dart A M, Davies B H
出版信息
Thorax. 1981 Oct;36(10):741-4. doi: 10.1136/thx.36.10.741.
Abstract
The bronchodilation produced by increasing intravenous doses of aminophylline, salbutamol, and a combination of aminophylline and salbutamol given in random order was determined in 10 stable asthmatics on three consecutive days. On a fourth day, response to placebo injections was determined. Forced expiratory volume in one second (FEV1) was measured at two-minute intervals after each dose until FEV1 returned to a new baseline. At no dosage level was there synergy between the two agents in terms of either mean percentage increase in FEV1 or the integrated response. The failure to demonstrate synergy has implications both with respect to the clinical use and the underlying mechanism of action of these drugs.
摘要
在10名病情稳定的哮喘患者中，连续三天按随机顺序静脉注射递增剂量的氨茶碱、沙丁胺醇以及氨茶碱与沙丁胺醇的组合，测定其支气管扩张作用。在第四天，测定患者对安慰剂注射的反应。每次给药后每隔两分钟测量一次一秒用力呼气量（FEV1），直至FEV1恢复到新的基线水平。在任何剂量水平下，就FEV1的平均百分比增加或综合反应而言，两种药物之间均未显示出协同作用。未能证明协同作用对于这些药物的临床应用和潜在作用机制均具有影响。
相似文献
1
Intravenous salbutamol and aminophylline in asthma: a search for synergy.静脉注射沙丁胺醇与氨茶碱治疗哮喘：寻找协同作用
Thorax. 1981 Oct;36(10):741-4. doi: 10.1136/thx.36.10.741.
2
Additive interaction of aminophylline and salbutamol in asthma: an in vivo study using dose-response curves.氨茶碱与沙丁胺醇在哮喘中的相加作用：一项使用剂量反应曲线的体内研究。
J Int Med Res. 1979;7 Suppl 1:52-5.
3
Does aminophylline benefit adults admitted to the hospital for an acute exacerbation of asthma?氨茶碱对因哮喘急性加重而住院的成年人有益吗？
Ann Intern Med. 1993 Dec 15;119(12):1155-60. doi: 10.7326/0003-4819-119-12-199312150-00001.
4
Treatment of acute asthma. Lack of therapeutic benefit and increase of the toxicity from aminophylline given in addition to high doses of salbutamol delivered by metered-dose inhaler with a spacer.急性哮喘的治疗。除了使用带储雾罐的定量吸入器给予高剂量沙丁胺醇外，加用氨茶碱并无治疗益处，反而会增加毒性。
Chest. 1994 Oct;106(4):1071-6. doi: 10.1378/chest.106.4.1071.
5
Aminophylline, salbutamol and combined intravenous infusions in acute severe asthma.氨茶碱、沙丁胺醇及联合静脉输注治疗急性重症哮喘
Br J Dis Chest. 1980 Oct;74(4):385-9.
6
Inhaled albuterol and oral prednisone therapy in hospitalized adult asthmatics. Does aminophylline add any benefit?
Chest. 1990 Dec;98(6):1317-21. doi: 10.1378/chest.98.6.1317.
7
Aminophylline vs. salbutamol in exercise-induced asthma.氨茶碱与沙丁胺醇治疗运动诱发性哮喘的比较
Int J Clin Pharmacol Ther Toxicol. 1980 Oct;18(10):442-6.
8
Effect of oral salbutamol and slow-release aminophylline on exercise tolerance in chronic bronchitis.口服沙丁胺醇和缓释氨茶碱对慢性支气管炎患者运动耐量的影响。
Thorax. 1981 Oct;36(10):787-9. doi: 10.1136/thx.36.10.787.
9
Interaction between proxyphylline and salbutamol.
Int J Clin Pharmacol Ther Toxicol. 1981 Aug;19(8):346-9.
10
Dose related effects of salbutamol and ipratropium bromide on airway calibre and reactivity in subjects with asthma.沙丁胺醇和异丙托溴铵对哮喘患者气道口径及反应性的剂量相关效应。
Thorax. 1988 Apr;43(4):300-5. doi: 10.1136/thx.43.4.300.
引用本文的文献
1
Recent advances in respiratory medicine.呼吸医学的最新进展。
Postgrad Med J. 1983 Jan;59(687):1-16. doi: 10.1136/pgmj.59.687.1.
2
The effect of posture on the sympathoadrenal response to theophylline infusion.姿势对茶碱输注时交感肾上腺反应的影响。
Br J Clin Pharmacol. 1983 Oct;16(4):405-11. doi: 10.1111/j.1365-2125.1983.tb02185.x.
3
Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects.吸入腺苷和鸟苷对正常人和哮喘患者气道阻力的影响。
Br J Clin Pharmacol. 1983 Feb;15(2):161-5. doi: 10.1111/j.1365-2125.1983.tb01481.x.
4
Tracheal relaxation from combinations of xanthines and of a beta 2-receptor agonist and xanthines.
Lung. 1986;164(1):33-40. doi: 10.1007/BF02713627.
5
The management of acute severe asthma.急性重症哮喘的管理
Postgrad Med J. 1985 Jul;61(717):599-606. doi: 10.1136/pgmj.61.717.599.
6
Theophylline in the management of airflow obstruction. 2. Difficult drugs to use, few clinical indications.茶碱在气流阻塞管理中的应用。2. 用药困难，临床适应证少。
BMJ. 1990 Apr 7;300(6729):929-31. doi: 10.1136/bmj.300.6729.929.
7
Phosphodiesterase inhibitors: new opportunities for the treatment of asthma.磷酸二酯酶抑制剂：治疗哮喘的新机遇
Thorax. 1991 Jul;46(7):512-23. doi: 10.1136/thx.46.7.512.
本文引用的文献
1
Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.生物材料中的3',5'-磷酸腺苷。I. 环3',5'-核苷酸磷酸二酯酶的纯化及性质，以及用该酶鉴定人尿中的3',5'-磷酸腺苷
J Biol Chem. 1962 Apr;237:1244-50.
2
Synergism and potentiation with special reference to the combination of structural analogues.协同作用与增效作用，特别涉及结构类似物的组合
Pharmacol Rev. 1956 Sep;8(3):339-87.
3
The effect of 3,7-dimethyl-1-(5-oxo-hexyl)-xanthin on the -adrenergic receptors and on the activity of isoprenaline.3,7-二甲基-1-(5-氧代己基)-黄嘌呤对β-肾上腺素能受体及异丙肾上腺素活性的影响。
Arch Int Pharmacodyn Ther. 1971 Nov;194(1):174-80.
4
Cyclic adenosine 3',5'-monophosphate in human lung.人肺中的环磷酸腺苷
Biochim Biophys Acta. 1971 Oct;252(1):160-4. doi: 10.1016/0304-4165(71)90104-8.
5
Histamine release in vitro: inhibition by catecholamines and methylxanthines.体外组胺释放：儿茶酚胺和甲基黄嘌呤的抑制作用
Science. 1968 Aug 30;161(3844):902-3. doi: 10.1126/science.161.3844.902.
6
The regulation of the calcium conductance of cardiac muscle by adrenaline.肾上腺素对心肌钙电导的调节
J Physiol. 1977 Jan;264(1):49-62. doi: 10.1113/jphysiol.1977.sp011657.
7
Adrenoceptors.肾上腺素能受体
Annu Rev Pharmacol Toxicol. 1978;18:291-311. doi: 10.1146/annurev.pa.18.040178.001451.
8
Interaction between isoprenaline and aminophylline in asthma.异丙肾上腺素与氨茶碱在哮喘中的相互作用。
Thorax. 1977 Aug;32(4):424-8. doi: 10.1136/thx.32.4.424.
9
Cardiac adenosine 3':5'-monophosphate. Free and bound forms in the isolated rat atrium.心脏3':5'-单磷酸腺苷。离体大鼠心房中的游离形式和结合形式
J Biol Chem. 1977 Feb 10;252(3):1041-50.
Zotero 插件