Plewig G, Lincke H, Wolff H H
Acta Derm Venereol. 1977;57(5):413-9.
The case is reported of a man with uniformly silver-blue discolouration of all fingernails, with deeper colouring over the lunulae. The nail bed changes resulted from the uncontrolled ingestion of a silver-containing granular powder. The total silver intake was over 15 g. The only other sign of argyrosis was a barely perceptible greyish discolouration over the cheeks and in the sclerae. Biopsies were taken from the nail bed and the cheek. Electron microscopy revealed metallic deposits in elastic fibres and basement membranes. The silver deposition was much heavier in the nail bed than in facial skin. Long-wave ultraviolet light (UVA) and lack of melanin protection seem to be responsible for this phenomenon. Argyrosis and the differential diagnosis of nail discolourations are reviewed.
报告了一例所有指甲均呈现均匀银蓝色变色、甲半月处颜色更深的病例。甲床变化是由于无节制摄入含银颗粒粉末所致。银的总摄入量超过15克。银质沉着病的唯一其他体征是脸颊和巩膜上有轻微的灰白色变色。对甲床和脸颊进行了活检。电子显微镜检查发现弹性纤维和基底膜中有金属沉积物。甲床中的银沉积比面部皮肤中的要重得多。长波紫外线（UVA）和缺乏黑色素保护似乎是造成这种现象的原因。本文对银质沉着病及指甲变色的鉴别诊断进行了综述。
