Johnson M W, Friedman P A, Mitch W E
Am J Gastroenterol. 1981 Dec;76(6):530-3.
An alcoholic patient developed severe hepatitis and renal failure after ingesting the contents of a 300 ml. bottle of Nyquil for its ethanol content. This illness was presumably related to the 6 gm. of acetaminophen contained in this nonprescription preparation. Although hepatic damage with or without renal failure is usually described after a massive overdose of acetaminophen, the changes in drug metabolism induced by chronic ethanol consumption may increase the risk for acetaminophen toxicity. The large number of nonprescription acetaminophen-ethanol preparations available should be considered in evaluating an alcoholic patient seen with acute hepatic and renal dysfunction.
一名酗酒患者因摄入一瓶300毫升的奈奎尔（Nyquil）中的乙醇成分而出现严重肝炎和肾衰竭。这种疾病可能与这种非处方制剂中含有的6克对乙酰氨基酚有关。虽然通常在对乙酰氨基酚大量过量服用后描述有或无肾衰竭的肝损伤，但慢性乙醇消耗引起的药物代谢变化可能会增加对乙酰氨基酚毒性的风险。在评估患有急性肝肾功能障碍的酗酒患者时，应考虑到有大量非处方的对乙酰氨基酚 - 乙醇制剂。
