对乙酰氨基酚相关性肝损伤：两例显示不寻常汇管区反应的报告

Acetaminophen associated hepatic injury, Report of two cases showing unusual portal tract reactions.

作者信息

Gerber M A, Kaufmann H, Klion F, Alpert L I

出版信息

Hum Pathol. 1980 Jan;11(1):37-42. doi: 10.1016/s0046-8177(80)80103-1.

Abstract

Two patients experienced acute transient hepatic and renal failure following ingestion of substantial but less than the usually toxic doses of acetaminophen, in both cases associated with heavy acute alcohol intake. One patient developed transient clinical features of chronic active liver disease one month later. Liver biopsy specimens from both patients taken after the acute episodes revealed, in addition to the well recognized centrilobular hepatic injury of acetaminophen, unusual portal tract lesions, which resembled chronic active hepatitis in one case. In some patients therapeutic doses of acetaminophen, if taken together with alcohol, may produce acute and chronic liver disease.

摘要

两名患者在摄入大量但低于通常中毒剂量的对乙酰氨基酚后出现急性短暂性肝肾功能衰竭，两例均与大量急性酒精摄入有关。其中一名患者在一个月后出现了慢性活动性肝病的短暂临床特征。两名患者在急性发作后进行的肝活检标本显示，除了对乙酰氨基酚引起的众所周知的小叶中心性肝损伤外，还有不寻常的门静脉病变，其中一例类似于慢性活动性肝炎。在一些患者中，治疗剂量的对乙酰氨基酚如果与酒精一起服用，可能会导致急性和慢性肝病。