Rothhammer A, Weis K H, Skrobek W
Anaesthesist. 1981 Dec;30(12):619-22.
Tramadol-HCl was used clinically in the form of a continuous infusion as the analgesic component of a balanced anaesthetic technique. In over 90% of the anaesthetics a further injection of barbiturate and/or supplementary muscle relaxant was necessary because the patients did not tolerate the operative procedure. Although a higher dosage of Tramadol reduces significantly the supplementary barbiturate dosage per kilogram bodyweight per minute which is required, it has no effect on the incidence of reflex movements, nor does it prevent the marked intraoperative rise of diastolic blood pressure. The balanced anaesthetic with Tramadol-HCl is characterized by prompt awakening, total amnesia, good post-operative analgesia and minimal side effects (occasional nausea). In particular, there was no case in which there was noticeable respiratory depression. As insufficient analgesia and hypnosis is provided by Tramadol-HCl, making the administration of muscle relaxants and barbiturates obligatory, there is no significant advance in our technique of using Tramadol-HCl, despite the advantages which have been outlined.
盐酸曲马多在临床上以持续输注的形式用作平衡麻醉技术中的镇痛成分。在超过90%的麻醉中，由于患者无法耐受手术过程，需要进一步注射巴比妥酸盐和/或补充肌肉松弛剂。尽管较高剂量的曲马多可显著降低每分钟每千克体重所需的补充巴比妥酸盐剂量，但它对反射运动的发生率没有影响，也不能防止术中舒张压明显升高。含盐酸曲马多的平衡麻醉的特点是苏醒迅速、完全遗忘、术后镇痛良好且副作用最小（偶尔有恶心）。特别是，没有出现明显呼吸抑制的病例。由于盐酸曲马多提供的镇痛和催眠不足，使得必须使用肌肉松弛剂和巴比妥酸盐，尽管已概述了其优点，但在我们使用盐酸曲马多的技术方面并没有显著进展。
