S'iakste T G
Biull Eksp Biol Med. 1981 Dec;92(12):714-5.
The changes in the molecular weight of DNA one-strand fragments were studied after a short-term incubation of 101/H and CBA mouse cells with embichin (nitrogen mustard). Unlike CBA mouse cells in which the repair of DNA lesions is completed after 24 hours, DNA in 101/H mouse cells was shown to be strongly fragmented. It is assumed that the deficiency of the repair of DNA lesions induced by embichin in 101H/ mouse cells is due to the deficiency of the last stage of excision repair, namely of the ligase reaction or to the uncoordinated pattern of the endonuclease and ligase reactions.
在用恩比兴（氮芥）对101/H和CBA小鼠细胞进行短期培养后，研究了DNA单链片段分子量的变化。与CBA小鼠细胞在24小时后完成DNA损伤修复不同，101/H小鼠细胞中的DNA显示出强烈的片段化。据推测，恩比兴在101H/小鼠细胞中诱导的DNA损伤修复缺陷是由于切除修复最后阶段的缺陷，即连接酶反应的缺陷，或者是由于内切核酸酶和连接酶反应的不协调模式。
