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[硫代磷酰胺诱导的101/H和CBA小鼠胚胎成纤维细胞DNA损伤的修复]

[Repair of DNA injuries induced by thiophosphamide in embryonal fibroblasts of 101/H and CBA mice].

作者信息

S'iakste T G

出版信息

Biull Eksp Biol Med. 1982 Jan;93(1):68-70.

PMID:6802201
Abstract

A study was made of changes in the molecular weight of one-strand fragments of DNA after a short-term treatment with thiophosphamide given in high concentrations of 101/H and CBA mouse cells. The data obtained indicate that DNA lesions induced by thiophosphamide occur and increase with time. It is assumed that the site of lesion is inter-strand cross-links of DNA. Mouse cells were disclosed to be able to repair the thiophosphamide-induced DNA lesions. Repair of DNA cross-links proceeds more effectively in 101/H mouse cells than in those of CBA mice.

摘要

对101/H高浓度硫磷酰胺短期处理后的CBA小鼠细胞中DNA单链片段分子量变化进行了研究。所得数据表明，硫磷酰胺诱导的DNA损伤会随着时间的推移而出现并增加。推测损伤部位是DNA的链间交联。发现小鼠细胞能够修复硫磷酰胺诱导的DNA损伤。101/H小鼠细胞中DNA交联的修复比CBA小鼠细胞更有效。

相似文献

1
[Repair of DNA injuries induced by thiophosphamide in embryonal fibroblasts of 101/H and CBA mice].[硫代磷酰胺诱导的101/H和CBA小鼠胚胎成纤维细胞DNA损伤的修复]
Biull Eksp Biol Med. 1982 Jan;93(1):68-70.
2
[Repair of embichin-induced DNA damage in embryonal fibroblasts of 101/H and CBA mice].[101/H和CBA小鼠胚胎成纤维细胞中恩比兴诱导的DNA损伤修复]
Biull Eksp Biol Med. 1981 Dec;92(12):714-5.
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[Chromosome aberrations and molecular weight of single-stranded DNA fragments in embryonal fibroblasts of mouse strains 101/H and CBA].
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Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N',N"-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo.逆转录病毒介导的碱基切除修复蛋白、甲酰胺嘧啶DNA糖基化酶或人氧鸟嘌呤DNA糖基化酶的表达，在体外和体内均可保护造血细胞免受N,N',N"-三乙烯硫代磷酰胺（噻替派）诱导的毒性作用。
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