剂量反应关系的建模。
Modeling of dose-response relationships.
作者信息
Altshuler B
出版信息
Environ Health Perspect. 1981 Dec;42:23-7. doi: 10.1289/ehp.814223.
Abstract
The main dose-response models for chronic toxicity are considered. For dichotomous response, the log probit, multi-hit, and multistage models are presented. For time-to-occurrence response, the log-normal and three variations of multistage models are presented. Finally, the Cornfield hockey-stick model is considered, and, for low-dose extrapolation, it is suggested that response be taken to be proportional to dose and to a power of time determined by background response.
摘要
考虑了慢性毒性的主要剂量-反应模型。对于二分反应，给出了对数概率模型、多击中模型和多阶段模型。对于发生时间反应，给出了对数正态模型和多阶段模型的三种变体。最后，考虑了科恩菲尔德曲棍球棒模型，对于低剂量外推，建议反应与剂量以及由背景反应确定的时间幂成正比。
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